Ammonia → 1,5,6,7-Tetrahydro-4H-indol-4-one
반응식
C(O[CH:4]1[CH2:12][C:11]2[C:10](=O)[CH2:9][CH2:8][CH2:7][C:6]=2[O:5]1)C.C(OC(OCC)CC1C(=O)CCCC1=O)C.[NH3:30]>CO>[O:5]=[C:6]1[CH2:7][CH2:8][CH2:9][C:10]2[NH:30][CH:4]=[CH:12][C:11]1=2참가 물질
5
반응 조건
- 온도
- 100 °C
실험 절차
The reactions of Examples 1 and 3 were respectively repeated and the reaction products were admixed in a molar (1)/(2) ratio of 87.6:12.4. Then, 1014 mg of this mixture of 2-ethoxy-4-oxo-2,3,4,5,6,7-hexahydrocoumarone and 2-(2',2'-diethoxyethyl)-1,3-cyclohexanedione, 1.7 ml of liquid ammonia and 5.5 ml of methanol were admixed in a glass tube which was sealed and heated at 100° C. for 1 hour and, then, at 150° C. for 16 hours. The above procedure provided 357.6 mg of 4-oxo-4,5,6,7-tetrahydroindole (yield 49%).
후처리
- customwhich was sealed
출처 및 근거
- ORD 기록
- ord-34db2fcc82ea45568d5b1563dcaf8f61
- 출처 데이터셋
- uspto-grants-1982_06
- 특허 번호
- US04336202
반응 노트
불러오는 중…