Ammonium Hydroxide → 5-(4-tert-BUTYLPHENYL)-3-ISOXAZOLECARBOXAMIDE
반응식
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[O:15][N:14]=[C:13]([C:16]([O:18]CC)=O)[CH:12]=2)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[OH-].[NH4+:22]>O>[C:1]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[O:15][N:14]=[C:13]([C:16]([NH2:22])=[O:18])[CH:12]=2)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2]참가 물질
4
실험 절차
Ethyl 5-(4-tert-butylphenyl)-3-isoxazolecarboxylate (25 grams) was mixed with 1 liter of concentrated ammonium hydroxide, and the reaction mixture stirred overnight (about 18 hours) at room temperature. The reaction mixture was then poured into 1 liter of water. The product precipitated and was separated by filtration, yield, 34 grams. The structure of the product was confirmed by NMR.
후처리
- customThe product precipitated
- customwas separated by filtration
- customyield
출처 및 근거
- ORD 기록
- ord-310fee898a5f45d29ad52811917a6b0e
- 출처 데이터셋
- uspto-grants-1982_06
- 특허 번호
- US04336264
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