3-(4-Fluorophenyl)-1,2-oxazol-5-amine → HCID 12960069, 화합물

HRID 1156535노트

반응식

HRID 1156535 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:12]=[C:11]([NH2:13])[O:10][N:9]=2)=[CH:4][CH:3]=1.[Cl:14][C:15]1[CH:25]=[CH:24][CH:23]=[CH:22][C:16]=1[C:17]([N:19]=[C:20]=[O:21])=[O:18]>C(OCC)(=O)C>[Cl:14][C:15]1[CH:25]=[CH:24][CH:23]=[CH:22][C:16]=1[C:17]([NH:19][C:20]([NH:13][C:11]1[O:10][N:9]=[C:8]([C:5]2[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=2)[CH:12]=1)=[O:21])=[O:18]

참가 물질

4

반응물 2

HCID 20603323-(4-Fluorophenyl)-1,2-oxazol-5-amineHCID 99423112-Chlorobenzoyl isocyanate

생성물 1

HCID 12960069HCID 12960069, 화합물

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

3-(4-Fluorophenyl)-5-aminoisoxazole (250 g.) was combined with 300 g. of 2-chlorobenzoyl isocyanate in 50 ml. of ethyl acetate. The reaction mixture was stirred overnight (about 17 hours) and the resulting solid was filtered, washed with ethanol, ether, and then dried, m.p., 200°-202° C.

후처리

  1. filtrationthe resulting solid was filtered
  2. washwashed with ethanol, ether
  3. customdried
  4. custom200°-202° C.

출처 및 근거

ORD 기록
ord-fd9cae1f2a7d45559ffaa0502cdf076f
출처 데이터셋
uspto-grants-1982_06
특허 번호
US04336264

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