Methanol → HCID 20534996, 화합물

HRID 1156566노트

반응식

HRID 1156566 반응식
[C:1]([NH:4][C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27])=[CH:7][C:6]=1[OH:28])(=[O:3])[CH3:2].[CH3:29][C:30]([C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1)=[CH2:31].CO>C1(C)C=CC=CC=1>[C:1]([NH:4][C:5]1[CH:10]=[C:9]([C:30]([CH3:31])([CH3:29])[C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)[C:8]([O:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27])=[CH:7][C:6]=1[OH:28])(=[O:3])[CH3:2]

참가 물질

5

반응물 3

HCID 887MethanolHCID 7407Alpha-MethylstyreneHCID 13765207N-[4-(Hexadecyloxy)-2-hydroxyphenyl]acetamide

생성물 1

HCID 20534996HCID 20534996, 화합물

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

In 150 ml of toluene was dissolved 20 g of 2-acetylamino-5-hexadecyloxyphenol obtained in Preparation Example 3, and it was then heated at 80°-90° C. together with 8 g of Amberlyst 15 (produced by Rohm & Haas Co.). To this mixture was added dropwise 30 ml of α-methylstyrene, and the resulting mixture was heated as it is for about 7 hours. After the reaction was completed, Amberlyst 15 was removed by filtration and the filtrate was condensed. After the addition of methanol, the condensed filtrate was cooled with ice whereupon the desired product precipitated. The product was collected by filtration and washed well with methanol. Yield: 6.6 g.

후처리

  1. customobtained in Preparation Example 3, and it
  2. temperaturewas then heated at 80°-90° C. together with 8 g of Amberlyst 15 (produced by Rohm & Haas Co.)
  3. temperaturethe resulting mixture was heated as it
  4. customAmberlyst 15 was removed by filtration
  5. customcondensed

출처 및 근거

ORD 기록
ord-1b39174e811b42debcc292f460daa32f
출처 데이터셋
uspto-grants-1982_06
특허 번호
US04336322

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