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[CH3:1][S:2]([OH:5])(=[O:4])=[O:3].[CH2:6]([N:13]([CH2:15][C:16]([C:18]1[CH:23]=[CH:22][C:21]([OH:24])=[C:20]([OH:25])[CH:19]=1)=[O:17])[CH3:14])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.[CH3:26][C:27]([CH3:34])([CH2:31][CH2:32][CH3:33])[C:28](Cl)=[O:29].[CH3:35][C:36]([CH3:43])([CH2:40][CH2:41][CH3:42])[C:37](O)=[O:38]>>[CH3:1][S:2]([OH:5])(=[O:4])=[O:3].[C:6]([N:13]([CH2:15][C:16]([C:18]1[CH:23]=[CH:22][C:21]([O:24][C:28](=[O:29])[C:27]([CH3:34])([CH3:26])[CH2:31][CH2:32][CH3:33])=[C:20]([O:25][C:37](=[O:38])[C:36]([CH3:43])([CH3:35])[CH2:40][CH2:41][CH3:42])[CH:19]=1)=[O:17])[CH3:14])(=[O:3])[C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=1참가 물질
실험 절차
Using a procedure similar to that described above in Example 3A, 3,4-dihydroxyphenyl N-benzyl-N-methylaminomethyl ketone methanesulfonate is reacted with two mole equivalents of 2,2-dimethylpentanoyl chloride in 2,2-dimethylpentanoic acid to yield 3,4-bis(2,2-dimethylpentanoyloxy)phenyl N-benzoyl-N-methylaminomethyl ketone methanesulfonate as a white crystalline solid. This salt is debenzylated by catalytic hydrogenation in the presence of palladium-on-charcoal hydrogenation catalyst, in the same manner as the debenzylation procedure described above in Example 124, to yield 3,4-bis(2,2-dimethylpentanoyloxy)-phenyl methylaminomethyl ketone methanesulfonate as a white crystalline solid. This salt is catalytically hydrogenated in anhydrous ethyl alcohol in the presence of 10 percent palladium-on-charcoal hydrogenation catalyst until one mole equivalent of hydrogen is absorbed. There is thus obtained 3,4-bis(2,2-dimethylpentanoyloxy)-alpha-(methylaminomethyl)benzyl alcohol methanesulfonate as a white crystalline solid.
출처 및 근거
- ORD 기록
- ord-2700a6e565e24e068b55ce7ca4ebee86
- 출처 데이터셋
- uspto-grants-1982_06
- 특허 번호
- US04336400
연결된 노트
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