Sodium Cyanide → 1-(4-Flurophenyl)isoquinoline-5-acetonitrile

반응식

[C-:1]#[N:2].[Na+].[F:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[C:20]3[C:15](=[C:16]([CH2:21]Cl)[CH:17]=[CH:18][CH:19]=3)[CH:14]=[CH:13][N:12]=2)=[CH:7][CH:6]=1>>[F:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[C:20]3[CH:19]=[CH:18][CH:17]=[C:16]([CH2:21][C:1]#[N:2])[C:15]=3[CH:14]=[CH:13][N:12]=2)=[CH:7][CH:6]=1

참가 물질

반응물 2

HCID 8929Sodium Cyanide

HCID 12851836HCID 12851836, 화합물

생성물 1

HCID 127989611-(4-Flurophenyl)isoquinoline-5-acetonitrile

실험 절차

Sodium cyanide and 1-(4-fluorophenyl)-5-chloromethylisoquinoline were reacted in the same way as in step (b) in Example 2 to afford 1-(4-flurophenyl)isoquinoline-5-acetonitrile having a melting point of 136° to 136.5° C.

출처 및 근거

ORD 기록: ord-1019ff16f32548b1a9af4579007a1d27
출처 데이터셋: uspto-grants-1982_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04337256

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