1-Phenyl-5-methoxycarbonylisoquinoline → 1-n-Propylisoquinoline-5-acetonitrile

HRID 1156930노트

반응식

HRID 1156930 반응식
[C:1]1([C:7]2[C:16]3[C:11](=[C:12]([C:17](OC)=O)[CH:13]=[CH:14][CH:15]=3)[CH:10]=[CH:9][N:8]=2)[CH:6]=[CH:5]C=CC=1.C1([C:27]2C3C(=C(CO)C=CC=3)C=C[N:28]=2)C=CC=CC=1>>[CH2:1]([C:7]1[C:16]2[CH:15]=[CH:14][CH:13]=[C:12]([CH2:17][C:27]#[N:28])[C:11]=2[CH:10]=[CH:9][N:8]=1)[CH2:6][CH3:5]

참가 물질

3

반응물 2

HCID 128518481-Phenyl-5-methoxycarbonylisoquinolineHCID 12851849HCID 12851849, 화합물

생성물 1

HCID 205338731-n-Propylisoquinoline-5-acetonitrile

실험 절차

1-Amino-2-(2-hydroxymethylphenyl)ethane and butyryl chloride were successively reacted in the same way as in steps (b) and (c) of Example 12 to afford 1-butyrylamino-2-(2-hydroxymethylphenyl)ethane as an oil. The product was successively reacted in the same way as in steps (d), (e), (f) and (g) of Example 12 to afford 1-n-propylisoquinoline-5-acetonitrile.

출처 및 근거

ORD 기록
ord-c4c04884ced14733941523b6c5a1de4e
출처 데이터셋
uspto-grants-1982_06
특허 번호
US04337256

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