4-(Trifluoromethyl)benzoyl chloride → 1-(4-Trifluoromethylbenzoyl)amino-2-(2-hydroxymethylphenyl)ethane

반응식

[NH2:1][CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[CH2:10][OH:11].[F:12][C:13]([F:24])([F:23])[C:14]1[CH:22]=[CH:21][C:17]([C:18](Cl)=[O:19])=[CH:16][CH:15]=1.C1(C2C3C(=C(Cl)C=CC=3)CCN=2)C=CC=CC=1>>[F:12][C:13]([F:23])([F:24])[C:14]1[CH:22]=[CH:21][C:17]([C:18]([NH:1][CH2:2][CH2:3][C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=2[CH2:10][OH:11])=[O:19])=[CH:16][CH:15]=1

참가 물질

반응물 3

HCID 676074-(Trifluoromethyl)benzoyl chloride

HCID 12832783[2-(2-Aminoethyl)phenyl]methanol

HCID 149989111-Phenyl-5-chloro-3,4-dihydroisoquinoline

생성물 1

HCID 205339401-(4-Trifluoromethylbenzoyl)amino-2-(2-hydroxymethylphenyl)ethane

실험 절차

1-Amino-2-(2-hydroxymethylphenyl)ethane and 4-trifluoromethylbenzoyl chloride were successively reacted in the same way as in steps (b) and (c) of Example 12 to afford 1-(4-trifluoromethylbenzoyl)amino-2-(2-hydroxymethylphenyl)ethane having a melting point of 145.8° to 146.3° C. The product was successively reacted in the same way as in steps (d), (e), (f) and (g) of Example 12 to afford 1-(4-trifluoromethylphenyl)isoquinoline-5-acetonitrile having a melting point of 121.9° to 122.6° C.