3-Bromoanisole → HCID 178506722, 화합물

HRID 1156995노트

반응식

HRID 1156995 반응식
C([Li:5])CCC.[CH3:6][O:7][C:8]1[CH:9]=[C:10](Br)[CH:11]=[CH:12][CH:13]=1>CCCCCC>[CH3:6][O:7][C:8]1[CH:9]=[C:10]([Li:5])[CH:11]=[CH:12][CH:13]=1

참가 물질

4

반응물 2

HCID 169713-BromoanisoleHCID 178418339Butyllithium

생성물 1

HCID 178506722HCID 178506722, 화합물

시약·촉매·용매 1

HCID 8058Hexane용매

실험 절차

A solution of 159 ml. of n-butyllithium in 100 ml. of hexane containing 47.7 g. of 3-methoxybromobenzene was stirred at -25° C. for twenty minutes and then was warmed to room temperature and stirred for one hour to provide 3-methoxyphenyl lithium. The reaction mixture was chilled to 10° C. and stirred while a solution of 50 g. of 1-methyl-4-piperidone in 100 ml. of diethyl ether was added dropwise over thirty minutes. Following complete addition, the reaction mixture was stirred for two hours, and then was diluted with 50 ml. of saturated aqueous sodium chloride solution. The solution was extracted several times with diethyl ether, and the ethereal extracts were combined and concentrated to dryness to provide 38 g. of 1-methyl-4-hydroxy-4-(3-methoxyphenyl)piperidine.

출처 및 근거

ORD 기록
ord-88bdb3e1ca7f4b668697dfba7c67fc9c
출처 데이터셋
uspto-grants-1982_06
특허 번호
US04337341

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