HCID 53650040, 화합물 → 3-(4-Chlorobenzoyl)-2-methylbenzene hexanoic acid

HRID 1157009노트

반응식

HRID 1157009 반응식
[Cl:1][C:2]1[CH:24]=[CH:23][C:5]([C:6]([C:8]2[C:9]([CH3:22])=[C:10]([CH:14]=[CH:15][CH2:16][CH2:17][CH2:18][C:19]([OH:21])=[O:20])[CH:11]=[CH:12][CH:13]=2)=[O:7])=[CH:4][CH:3]=1.[H][H]>C(O)C.[Pt]=O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([C:8]2[C:9]([CH3:22])=[C:10]([CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][C:19]([OH:21])=[O:20])[CH:11]=[CH:12][CH:13]=2)=[O:7])=[CH:23][CH:24]=1

참가 물질

5

반응물 2

HCID 53650040HCID 53650040, 화합물HCID 178418361HCID 178418361, 화합물

생성물 1

HCID 205344893-(4-Chlorobenzoyl)-2-methylbenzene hexanoic acid수율 79.5%

시약·촉매·용매 2

HCID 82844Platinum oxide (PtO)촉매HCID 702Ethanol용매

실험 절차

5.425 g of 6-[3'-(4-chlorobenzoyl)-2'-methyl-phenyl]-hex-5-enoic acid dissolved in 100 ml of ethanol in the presence of 110 mg of platinum oxide had hydrogen pased therethrough and then the catalyst was filtered off. The filtrate was evaporated to dryness and the residue was taken up in ether. The solution was treated with activated carbon, filtered and evaporated to dryness. The residue was crystallized from a 1:1 isopropyl ether-petroleum ether mixture to obtain 4.34 g of 6-[3'-(4-chlorobenzoyl)-2'-methyl-phenyl]-hexanoic acid melting at 82° C.

후처리

  1. filtrationthe catalyst was filtered off
  2. customThe filtrate was evaporated to dryness
  3. additionThe solution was treated with activated carbon
  4. filtrationfiltered
  5. customevaporated to dryness
  6. customThe residue was crystallized from a 1:1 isopropyl ether-petroleum ether mixture

출처 및 근거

ORD 기록
ord-def883ec1ffd482b914d837b78f3bf2f
출처 데이터셋
uspto-grants-1982_06
특허 번호
US04337353

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