Trifluoroacetic acid → 2-Piperidin-4-ylethynyl-pyrimidine

반응식

C(OC([N:8]1[CH2:13][CH2:12][CH:11]([C:14]#[C:15][C:16]2[N:21]=[CH:20][CH:19]=[CH:18][N:17]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>>[NH:8]1[CH2:13][CH2:12][CH:11]([C:14]#[C:15][C:16]2[N:17]=[CH:18][CH:19]=[CH:20][N:21]=2)[CH2:10][CH2:9]1

참가 물질

반응물 2

HCID 6422Trifluoroacetic acid

HCID 669398774-Pyrimidin-2-ylethynyl-piperidine-1-carboxylic acid tert-butyl ester

생성물 1

HCID 595113452-Piperidin-4-ylethynyl-pyrimidine

실험 절차

4-Pyrimidin-2-ylethynyl-piperidine-1-carboxylic acid tert-butyl ester was treated with TFA for 10 minutes and concentrated, lyophilized to provide the title product.

후처리

concentrationconcentrated

출처 및 근거

ORD 기록: ord-50c63af0e9b64b18ba7edfa48a6aaf77
출처 데이터셋: uspto-grants-2010_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07807672B2

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