N-methyl-2-pyrrolidone → HCID 178493790, 화합물
반응식
Cl.[CH3:2][O:3][C:4]1[CH:9]=[N:8][C:7]([O:10]C)=[C:6]2[NH:12][CH:13]=[CH:14][C:5]=12.CN1CCCC1=O>O>[OH:10][C:7]1[N:8]=[CH:9][C:4]([O:3][CH3:2])=[C:5]2[C:6]=1[NH:12][CH:13]=[CH:14]2참가 물질
4
반응 조건
- 온도
- 90 °C
실험 절차
To 4,7-dimethoxy-1H-pyrrolo[2,3-c]pyridine hydrochloride (50 g) taken in 2 L 3-necked round bottom flask, 250 ml N-methyl-2-pyrolidinone was added followed by 8 ml of water, and was heated to 90° C. for about 4 hrs. The reaction mixture was cooled to room temperature, diluted with water (1 L) and the whole mixture was kept in cold room for about one hour. The resulting solid was collected by filtration, washed with cold water and dried in vacuum oven at 50° C. for 4 hrs to afford 7-hydroxyl-4-methoxy-6-azaindole as white solid.
후처리
- temperatureThe reaction mixture was cooled to room temperature
- filtrationThe resulting solid was collected by filtration
- washwashed with cold water
- customdried in vacuum oven at 50° C. for 4 hrs
출처 및 근거
- ORD 기록
- ord-c722c929d6434091af2636e2d548bb34
- 출처 데이터셋
- uspto-grants-2010_10
- 특허 번호
- US07807671B2
반응 노트
불러오는 중…