Tributylamine → Clodronate

HRID 1157346

반응식

HRID 1157346 반응식
[Na+].[Na+].[Cl:3][C:4]([Cl:13])([P:9](=[O:12])([O-:11])[O-:10])[P:5](=[O:8])([OH:7])[OH:6].C(N(CCCC)CCCC)CCC>>[Cl:13][C:4]([Cl:3])([P:5](=[O:6])([OH:8])[OH:7])[P:9](=[O:10])([OH:11])[OH:12]

참가 물질

3

반응물 2

HCID 7622TributylamineHCID 73554303Dichloromethylenediphosphonic acid

생성물 1

HCID 25419Clodronate

실험 절차

An aqueous solution of dichloromethylenediphosphonic acid disodium salt (1.0 g, 3.46 mmol) was loaded on a column of DOWEX 50WX8-100 ion-exchange resin and eluted with water. Tributylamine (1.65 mL, 6.92 mmol) was added and the mixture was shaken vigorously. The resulting solution was concentrated to dryness and coevaporated with anhydrous DMF three times. The residue was dried under vacuum overnight.

후처리

  1. washeluted with water
  2. concentrationThe resulting solution was concentrated to dryness
  3. customThe residue was dried under vacuum overnight

출처 및 근거

ORD 기록
ord-eee9d7e1acb74bf79f8becde6b56a395
출처 데이터셋
uspto-grants-2010_10
특허 번호
US07807653B2

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