Cesium carbonate → tert-butyl3-{[4-chloro-3-(3-chloro-5-cyanophenoxy)-5-fluorophenoxy]methyl}-6-fluoro-1H-pyrazolo[3,4-b]pyridine-1-carboxylate

반응식

[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([O:10][C:11]2[CH:16]=[C:15]([OH:17])[CH:14]=[C:13]([F:18])[C:12]=2[Cl:19])[CH:9]=1)[C:5]#[N:6].C([O-])([O-])=O.[Cs+].[Cs+].Br[CH2:27][C:28]1[C:36]2[C:31](=[N:32][C:33]([F:37])=[CH:34][CH:35]=2)[N:30]([C:38]([O:40][C:41]([CH3:44])([CH3:43])[CH3:42])=[O:39])[N:29]=1>CN1C(=O)CCC1.CCOC(C)=O>[C:41]([O:40][C:38]([N:30]1[C:31]2=[N:32][C:33]([F:37])=[CH:34][CH:35]=[C:36]2[C:28]([CH2:27][O:17][C:15]2[CH:14]=[C:13]([F:18])[C:12]([Cl:19])=[C:11]([O:10][C:8]3[CH:7]=[C:4]([C:5]#[N:6])[CH:3]=[C:2]([Cl:1])[CH:9]=3)[CH:16]=2)=[N:29]1)=[O:39])([CH3:44])([CH3:43])[CH3:42]