1-Amino-3-methylpyridinium nitrate → N-{3-[3-(2-Chloro-4-pyrimidinyl)-6-methylpyrazolo[1,5-a]pyridin-2-yl]phenyl}-2,2,2-trifluoroacetamide

참여 물질

반응 단계

N-[3-(2-Chloro-pyrimidin-4-ylethenyl)-phenyl]-2,2,2-trifluoro-acetamide (5.00 g, 18.45 mmol) and 1-amino-3-methylpyridinium nitrate (6.19 g, 36.90 mmol) were combined in a procedure analogous to Example 67, Step A to afford 1.80 g of crude material, which was purified via HPLC separation to give N-{3-[3-(2-chloro-4-pyrimidinyl)-6-methylpyrazolo[1,5-a]pyridin-2-yl]phenyl}-2,2,2-trifluoroacetamide (1.70 g, 21%). 1H NMR (400 MHz, DMSO-d6) δ 11.37 (s, 1H), 8.73 (s, 1H), 8.43 (d, J=5.6 Hz, 1H), 8.28 (d, J=9.2 Hz, 1H), 7.92 (s, 1H), 7.83 (d, J=8.4 Hz, 1H), 7.56-7.49 (m, 2H), 7.45-7.40 (m, 1H), 7.03 (d, J=5.6 Hz, 1H), 2.37 (s, 3H).

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