Bromine → N-(4-Bromo-3-chloro-2-methylphenyl)acetamide
반응식
[Cl:1][C:2]1[C:3]([CH3:12])=[C:4]([NH:8][C:9](=[O:11])[CH3:10])[CH:5]=[CH:6][CH:7]=1.[Br:13]Br>C(O)(=O)C>[Br:13][C:7]1[CH:6]=[CH:5][C:4]([NH:8][C:9](=[O:11])[CH3:10])=[C:3]([CH3:12])[C:2]=1[Cl:1]참가 물질
4
반응 조건
- 온도
- 0 °C
실험 절차
Dissolve N-(3-chloro-2-methyl-phenyl)-acetamide (120.0 g, 0.653 mol) in acetic acid and cool to 0° C. Add bromine (313.3 g, 1.96 mol) dropwise over 30 min via an addition funnel. Stir for 17 h while allowing the reaction to warm to room temperature. Pour the reaction into 1 L of ice, and filter. Rinse the filter cake with 4 L of water. The title product is isolated in 93.6% yield (160.6 g) as a white solid. MS: MS (ESI−): 262 (M−1)−. MS (ESI+): 263 (M+1)+.
후처리
- customthe reaction
- temperatureto warm to room temperature
- additionPour
- filtrationfilter
- washRinse the filter cake with 4 L of water
출처 및 근거
- ORD 기록
- ord-d9d9c2b6c46f4c54b4b8b8dd8b802dde
- 출처 데이터셋
- uspto-grants-2010_10
- 특허 번호
- US07807691B2
반응 노트
불러오는 중…