Potassium Carbonate → 3'-(5-Bromo-pentyloxy)-4-methoxy-chalcone

HRID 1157986

반응식

HRID 1157986 반응식
[OH:1][C:2]1[CH:3]=[C:4]([CH:17]=[CH:18][CH:19]=1)[C:5](=[O:16])[CH:6]=[CH:7][C:8]1[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[CH:10][CH:9]=1.Br[C:21](Br)([CH2:24][CH3:25])[CH2:22][CH3:23].C(=O)([O-])[O-].[K+].[K+].[K+].[Br-:34]>CC(C)=O>[Br:34][CH2:23][CH2:22][CH2:21][CH2:24][CH2:25][O:1][C:2]1[CH:3]=[C:4]([CH:17]=[CH:18][CH:19]=1)[C:5](=[O:16])[CH:6]=[CH:7][C:8]1[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[CH:10][CH:9]=1

참가 물질

6

반응물 4

HCID 11430Potassium CarbonateHCID 253877Potassium BromideHCID 135557303,3-DibromopentaneHCID 686436623'-Hydroxy-4-methoxy-chalcone2회

생성물 1

HCID 686436193'-(5-Bromo-pentyloxy)-4-methoxy-chalcone

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

This compound (40) was prepared from 3′-hydroxy-4-methoxy-chalcone, 8 (2 g, 7.87 mmol), dibromo pentane (5.4 mL, 39.4 mmol) and potassium carbonate (2.2 g, 15.8 mmol) in dry acetone (100 mL) using the identical procedure as described for 39. Yield 2.7 g (85%); mp 83-84° C.; MS (FAB) 403/405 (M++1); IR (KBr) 1650; 1H NMR (200 MHz, CDCl3) δ 7.78 (d, J=15.6 Hz, 1H), 7.60 (d, J=8.7 Hz, 2H), 7.58 (d, J=7.4 Hz, 1H), 7.52 (d, J=2.2 Hz, 1H), 7.39 (t, J=7.8 Hz, 1H), 7.39 (d, J=15.6 Hz, 1H), 7.10 (dd, J=8.0 Hz, 2.3 Hz, 1H), 6.93 (d, J=8.7 Hz, 2H), 4.04 (t, J=6.2 Hz, 2H), 3.85 (s, 3H), 3.44 (t, J=6.7 Hz, 2H), 1.99-1.81 (m, 4H), 1.71-1.60 (m, 2H).

출처 및 근거

ORD 기록
ord-b22c4090dec1439d910b9b36b068814f
출처 데이터셋
uspto-grants-2010_10
특허 번호
US07807712B2

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