Triethylamine → HCID 178453727, 화합물

HRID 1158108

반응식

HRID 1158108 반응식
[CH:1]12[CH2:7][CH:4]([CH2:5][CH2:6]1)[CH2:3][C@@H:2]2[NH:8][C:9]1[S:10][C:11]([CH3:22])([CH2:15][CH:16]2CCNCC2)[C:12](=[O:14])[N:13]=1.[C:23]([NH:30][CH2:31][CH2:32][O:33][C:34]1[CH:42]=[CH:41][C:37](C(O)=O)=[CH:36][CH:35]=1)([O:25][C:26]([CH3:29])([CH3:28])[CH3:27])=[O:24].CCN=C=NCCCN(C)C.C1C=CC2N([OH:63])N=NC=2C=1.[CH2:64]([N:66]([CH2:69][CH3:70])[CH2:67][CH3:68])C>C(Cl)Cl>[CH:1]12[CH2:7][CH:4]([CH2:5][CH2:6]1)[CH2:3][C@@H:2]2[NH:8][C:9]1[S:10][C:11]([CH2:15][CH:16]2[CH2:70][CH2:69][N:66]([C:64]([C:41]3[CH:42]=[C:34]([CH:35]=[CH:36][CH:37]=3)[O:33][CH2:32][CH2:31][NH:30][C:23](=[O:24])[O:25][C:26]([CH3:27])([CH3:28])[CH3:29])=[O:63])[CH2:67][CH2:68]2)([CH3:22])[C:12](=[O:14])[N:13]=1

참가 물질

7

반응물 5

HCID 8471TriethylamineHCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 757711-HydroxybenzotriazoleHCID 27559974-(2-((tert-Butoxycarbonyl)amino)ethoxy)benzoic acidHCID 178422083HCID 178422083, 화합물

생성물 1

HCID 178453727HCID 178453727, 화합물수율 412.1%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A mixture of 2-((2S)-bicyclo[2.2.1]heptan-2-ylamino)-5-methyl-5-(piperidin-4-ylmethyl)thiazol-4(5H)-one (534 mg, 1.66 mmol), 4-[2-(Boc-amino)ethyloxy]-benzoic acid (NeoMPS, 701 mg, 2.49 mmol), EDCI (Aldrich, 637 mg, 3.32 mmol, 2.0 eq), HOBt (Aldrich, 45 mg, 0.332 mmol, 0.2 eq) and triethylamine (Aldrich, 336 mg, 3.32 mmol, 2.0 eq) in CH2Cl2 (10 mL) was stirred at room temperature for ca. 18 h. The reaction was quenched with saturated NaHCO3 (100 mL), and the crude product was extracted with CH2Cl2 (3×100 mL). The combined organic extracts were washed with brine, dried over Na2SO4, filtered, and concentrated. Flash column chromatography (silica gel, 0-5% MeOH in CH2Cl2) afforded the title compound as a white solid (800 mg). MS (ESI, pos. ion) m/z: 585 (M+H).

후처리

  1. customThe reaction was quenched with saturated NaHCO3 (100 mL)
  2. extractionthe crude product was extracted with CH2Cl2 (3×100 mL)
  3. washThe combined organic extracts were washed with brine
  4. dry with materialdried over Na2SO4
  5. filtrationfiltered
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-bbb4a65ec49d41fd99fb995156ae6844
출처 데이터셋
uspto-grants-2010_10
특허 번호
US07807700B2

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