Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → (3S*,4R*)-3-(tert-Butyl-dimethyl-silanyloxymethyl)-4-({isopropyl-[4-methoxy-3-(3-methoxy-propoxy)-benzoyl]-amino}-methyl)-pyrrolidine-1-carboxylic acid tert-butyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Bis(2-oxo-3-oxazolidinyl)phosphinic chloride | HCID 152842 | — |
| 반응물 | 4-Methoxy-3-(3-methoxypropoxy)benzoic acid | HCID 19039502 | — |
| 반응물 | (3S*,4R)-3-(tert-butyl-dimethyl-silanyloxymethyl)-4-(isopropylamino-methyl)-pyrrolidine-1-carboxylic acid tert-butyl ester | HCID 131728361 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | (3S*,4R*)-3-(tert-Butyl-dimethyl-silanyloxymethyl)-4-({isopropyl-[4-methoxy-3-(3-methoxy-propoxy)-benzoyl]-amino}-methyl)-pyrrolidine-1-carboxylic acid tert-butyl ester | HCID 131728362 | — |
반응 단계
The title compound is prepared in a similar manner as described for Example 9/reaction step G, from ((3S*,4R)-3-(tert-butyl-dimethyl-silanyloxymethyl)-4-(isopropylamino-methyl)-pyrrolidine-1-carboxylic acid tert-butyl ester (22.9 g, 59.1 mmol), 3-(3-methoxy-propoxy)-4-methoxy-benzoic acid (15.6 g, 65.1 mmol), bis(2-oxo-3-oxazolidinyl)phosphinic chloride (16.6 g, 65.1 mmol) and triethylamine (19.6 mL, 237 mmol) in CH2Cl2 (0.6 L) as a yellowish oil. MS: 609.4 [M+H]+; tR (HPLC, C18 column, 5-100% CH3CNIH2O/6 min, 100% CH3CN/23 min, CH3CN and H2O containing 0.1% TFA, flow: 1 mL/min): 7.06 min.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07807709B2 |
| 출처 데이터셋 | uspto-grants-2010_10 |
| ORD ID | ord-c960999cf2b74b7892bca0cac2318966 |
| 출처 메모 | uspto-grants-2010_10 |