Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
tert-Butyl Formate → (3S*,4R*)-3-formyl-4-({isopropyl-[4-methoxy-3-(3-methoxy-propoxy)-benzoyl]-amino}-methyl)-pyrrolidine-1-carboxylic acid tert-butyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | tert-Butyl Formate | HCID 61207 | — |
| 반응물 | Triacetoxyperiodinane | HCID 159087 | — |
| 반응물 | Acetonitrile--water (1/1) | HCID 18373917 | — |
| 반응물 | (3S,4R)-3-Hydroxymethyl-4-({isopropyl-[4-methoxy-3-(3-methoxy-propoxy)-benzoyl]-amino}-methyl)-pyrrolidine-1-carboxylic acid tert-butyl ester | HCID 59512299 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | (3S*,4R*)-3-formyl-4-({isopropyl-[4-methoxy-3-(3-methoxy-propoxy)-benzoyl]-amino}-methyl)-pyrrolidine-1-carboxylic acid tert-butyl ester | HCID 59512275 | — |
반응 단계
The title compound is prepared in a similar manner as described for Example 9/reaction step I, from (3S*,4R*)-3-hydroxymethyl-4-({isopropyl-[4-methoxy-3-(3-methoxy-propoxy)-benzoyl]-amino}-methyl)-pyrrolidine-1-carboxylic acid tert-butyl ester (4.9 g, 9.95 mmol) and Dess-Martin periodinane (4.22 g, 9.95 mmol) in CH2Cl2 (30 mL), slowly wet CH2Cl2 (0.20 mL of water in 30 mL of CH2Cl2) as colorless oil. MS: 437.2 [M+H-BOC]+. tR (HPLC, Nucleosil C18 column, 5-100% CH3CN/H2O/6 min, 100% CH3CN/1.5 min, CH3CN and H2O containing 0.1% TFA, flow: 1.5 ml/min): 4.99 min.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07807709B2 |
| 출처 데이터셋 | uspto-grants-2010_10 |
| ORD ID | ord-5dad337c3a9f49ceb883707d9e914e2d |
| 출처 메모 | uspto-grants-2010_10 |