Acetonitrile → (3S)-3-acetamido-3-phenylpropanoic acid

HRID 1158369

반응식

HRID 1158369 반응식
[C:1]([NH:4][C:5]1([CH2:10][C:11]([OH:13])=[O:12])[CH2:9][CH2:8][CH2:7][CH2:6]1)(=[O:3])[CH3:2].N[C@H:15](C1C=CC=CC=1)[CH2:16]C(O)=O.CC#N.O.CC#N>O>[C:1]([NH:4][C@H:5]([C:9]1[CH:8]=[CH:7][CH:6]=[CH:16][CH:15]=1)[CH2:10][C:11]([OH:13])=[O:12])(=[O:3])[CH3:2]

참가 물질

6

반응물 4

HCID 6342AcetonitrileHCID 686704(3S)-3-amino-3-phenylpropanoic acidHCID 18373917Acetonitrile--water (1/1)HCID 451192642-(1-Acetamidocyclopentyl)acetic acid

생성물 1

HCID 746296(3S)-3-acetamido-3-phenylpropanoic acid

시약·촉매·용매 1

HCID 962Water용매

실험 절차

The title compound is prepared analogously as described for (1-acetylamino-cyclopentyl)-acetic acid from (S)-3-amino-3-phenylpropionic acid. MS (LC-MS): [M+H]+=208.2. tR (HPLC, -Waters Symmetry C18 column, 10-95% CH3CN/H2O/3.5 min, 95% CH3CNIH2O, 2 min, CH3CN and H2O containing 0.1% TFA, flow: 0.6 mL/min): 0.79 min.

후처리

  1. custom0.79 min.

출처 및 근거

ORD 기록
ord-460e098e16e04bf2bdf96351b219572b
출처 데이터셋
uspto-grants-2010_10
특허 번호
US07807709B2

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