Benzyl(cyclopropylmethyl)amine → Cyclopropyl-(tetrahydro-pyran-3-ylmethyl)-carbamoyl chloride

HRID 1158426노트

반응식

HRID 1158426 반응식
[CH2:1]([N:8]([CH:12]1[CH2:14][CH2:13]1)[C:9]([Cl:11])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=C[CH:3]=1.C1(NCC2CCC[O:22]C2)CC1.C(NCC1CC1)C1C=CC=CC=1>C(Cl)Cl.CO>[CH:12]1([N:8]([CH2:1][CH:2]2[CH2:7][CH2:6][CH2:5][O:22][CH2:3]2)[C:9]([Cl:11])=[O:10])[CH2:14][CH2:13]1

참가 물질

5

반응물 3

HCID 518069Benzyl(cyclopropylmethyl)amineHCID 10608488Benzyl-cyclopropyl-carbamoyl chlorideHCID 62760687N-((Tetrahydro-2H-pyran-3-yl)methyl)cyclopropanamine

생성물 1

HCID 86622397Cyclopropyl-(tetrahydro-pyran-3-ylmethyl)-carbamoyl chloride

시약·촉매·용매 1

HCID 21226129Dichloromethane methanol용매

실험 절차

The title compound is prepared analogously as described for benzyl-cyclopropyl-carbamoyl chloride starting from cyclopropyl-(tetrahydro-pyran-3-ylmethyl)-amine (prepared analogously as described for benzyl-cyclopropylmethyl-amine). TLC, Rf (CH2Cl2/MeOH 95:5)=0.9.

후처리

  1. customprepared analogously

출처 및 근거

ORD 기록
ord-c2c07643084041728ce1025edf36a2e9
출처 데이터셋
uspto-grants-2010_10
특허 번호
US07807709B2

반응 노트

불러오는 중…