Boron tribromide → 4-Ethyl-3-hydroxybenzoic acid
반응식
[CH2:1]([C:3]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=[O:8])=[CH:5][C:4]=1[O:12]CCCOC)[CH3:2].B(Br)(Br)Br>C(Cl)Cl>[CH2:1]([C:3]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=[O:8])=[CH:5][C:4]=1[OH:12])[CH3:2]참가 물질
4
실험 절차
To a solution of 4-ethyl-3-(3-methoxy-propoxy)-benzoic acid (6.44 g, 27.03 mmol) in CH2Cl2 (150 mL) at −78° C. is slowly added BBr3 (9 mL, 93.41 mmol). The reaction mixture is allowed to reach RT and stirred for 3 hours, then poured into ice/water and filtrated to afford the title product as a white solid. TLC, Rf (CH2Cl2/MeOH 95:5)=0.2.
후처리
- customat −78° C.
- customto reach RT
- filtrationfiltrated
출처 및 근거
- ORD 기록
- ord-d76ef5728a66498ba1ebf12bd22f6729
- 출처 데이터셋
- uspto-grants-2010_10
- 특허 번호
- US07807709B2
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