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2-Methoxypropene → HCID 59511564, 화합물

HRID 1158508
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HRID 1158508 반응식
[CH2:1]([C@:8]([OH:42])([CH2:22][CH2:23][O:24][Si:25]([C:38]([CH3:41])([CH3:40])[CH3:39])([C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1)[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)[C:9]([NH:11][C@H:12]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH2:14][C@H:13]1[OH:21])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:43]1(C)[CH:48]=CC(S(O)(=O)=O)=C[CH:44]=1.[NH+]1C=CC=CC=1.COC(C)=C.C([O-])(O)=O.[Na+]>ClCCl>[CH2:1]([C@:8]([OH:42])([CH2:22][CH2:23][O:24][Si:25]([C:38]([CH3:39])([CH3:41])[CH3:40])([C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)[C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1)[C:9]([N:11]1[C@H:12]2[C:20]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[CH2:14][C@H:13]2[O:21][C:43]1([CH3:48])[CH3:44])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 83002-MethoxypropeneHCID 516892Sodium BicarbonateHCID 22033616Pyridinium.p-toluenesulfonateHCID 44818262HCID 44818262, 화합물

생성물 1

HCID 59511564HCID 59511564, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a cooled (0° C.) solution of (S)-2-benzyl-4-(tert-butyl-diphenyl-silanyloxy)-2-hydroxy-N-((1S,2R)-2-hydroxy-indan-1-yl)-butyramide (21e) (0.325 g, 0.56 mmol) and pyridinium p-toluenesulphonic acid (15 mg, 0.05 mmol) in dry dichloromethane (20 mL), 2-methoxypropene (0.4 g, 5.6 mmol) was added and stirred for 6 h at the same temperature. Saturated NaHCO3 solution was added, organic layer and washed with sat. NaHCO3, brine, dried over anhydrous MgSO4 and evaporated under reduced pressure. The crude title product [(0.33 g), MS (ESI+): 620 (M+)] was used as such for the next reaction.

후처리

  1. additionwas added
  2. washorganic layer and washed with sat. NaHCO3, brine
  3. dry with materialdried over anhydrous MgSO4
  4. customevaporated under reduced pressure
  5. customsuch for the next reaction

출처 및 근거

ORD 기록
ord-dfae9ea596554fbf914102b8a1f25b49
출처 데이터셋
uspto-grants-2010_10
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07807677B2

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