2-Bromopropane → tert-butyl {(1S)-2-[2-amino-3-(aminocarbonyl)-9h-pyrido[2,3-b]indol-9-yl]-1-methylethyl}carbamate

참여 물질

역할	이름	HCID	투입량
반응물	2-Bromopropane	HCID 6358	—
반응물	(S)-(2-Iodo-1-methyl-ethyl)-carbamic acid tert-butyl ester	HCID 15529790	—
반응물	2-amino-9-isopropyl-9H-pyrido[2,3-b]indole-3-carboxamide	HCID 24900676	—
용매	Formic Acid	HCID 284	—
생성물	tert-butyl {(1S)-2-[2-amino-3-(aminocarbonyl)-9h-pyrido[2,3-b]indol-9-yl]-1-methylethyl}carbamate	HCID 59513639	—

반응 단계

tert-butyl{(1S)-2-[2-amino-3-(aminocarbonyl)-9H-pyrido[2,3-b]indol-9-yl]-1-methylethyl}carbamate (xvi-b) was prepared following the procedure detailed in the synthesis of 13 substituting tert-butyl [(1S)-2-iodo-1-methylethyl]carbamate for 2-bromopropane. HCOOH Standard Conditions. M+H=384. 1H NMR (300 MHz, d6-DMSO): δ 8.71 (s, 1H), 7.77 (d, J=7.3 Hz, 1H), 7.59 (d, J=7.9 Hz, 1H), 7.57-7.49 (br s, 2H), 7.31 (dd, J=7.9, 7.3 Hz, 1H), 7.16 (dd, J=7.9, 7.3 Hz, 1H), 6.90 (br d, 1H), 4.27 (dd, J=6.1, 13.4 Hz, 1H), 4.14-3.95 (m, 2H), 1.18 (s, 9H), 1.05 (d, J=6.1 Hz, 3

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07812018B2
출처 데이터셋	uspto-grants-2010_10
ORD ID	ord-5dfe036fb1f1471688e713945faa7781
출처 메모	uspto-grants-2010_10