Ammonia → Chroman-4-one O-methyl-oxime

HRID 1158801

반응식

HRID 1158801 반응식
[O:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4](=O)[CH2:3][CH2:2]1.C(C1C=C2C([C:20](=[O:26])CCO2)=CC=1)(C)(C)C.[NH3:27]>>[CH3:20][O:26][N:27]=[C:4]1[C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[O:1][CH2:2][CH2:3]1

참가 물질

4

반응물 3

HCID 222AmmoniaHCID 68110ChromanoneHCID 595485417-(Tert-butyl)chroman-4-one

생성물 1

HCID 54035320Chroman-4-one O-methyl-oxime

실험 절차

The title compound was prepared using the procedure as described in Example 1B, substituting chroman-4-one for the product of Example 1A. 1H NMR (300 MHz, d6-DMSO) δ 7.79 (dd, J=1.0 and 7.5 Hz, 1H), 7.28 (m, 1H), 6.90 (m, 2H), 4.18 (t, J 6.0 Hz, 2H), 3.90 (s, 3H, minor), 3.88 (s, 3H, major), 2.82 (t, J 6.0 Hz, 2H). MS (DCI/NH3) m/e 178 (M+H)+.

출처 및 근거

ORD 기록
ord-6bb8e7844ebe46a2a78f5a1cd64b60a4
출처 데이터셋
uspto-grants-2010_10
특허 번호
US07812019B2

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