Ammonium Chloride → 5-amino-1-methyl-3,6-dihydro-1H-pyrazin-2-one hydrochloride

HRID 1158864노트

반응식

HRID 1158864 반응식
CO[C:3]1[CH2:8][N:7]([CH3:9])[C:6](=[O:10])[CH2:5][N:4]=1.[Cl-:11].[NH4+:12]>C(O)C>[ClH:11].[NH2:12][C:3]1[CH2:8][N:7]([CH3:9])[C:6](=[O:10])[CH2:5][N:4]=1

참가 물질

4

반응물 2

HCID 25517Ammonium ChlorideHCID 219414705-methoxy-1-methyl-3,6-dihydro-1H-pyrazin-2-one

생성물 1

HCID 219413655-amino-1-methyl-3,6-dihydro-1H-pyrazin-2-one hydrochloride

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 5-methoxy-1-methyl-3,6-dihydro-1H-pyrazin-2-one (2.3 g) and ammonium chloride (936 mg) in dry ethanol (32 mL) was stirred at room temperature for 1 h and then refluxed for 2 h. The reaction mixture was cooled to room temperature and evaporated under reduced pressure. The residue was triturated with chloroform at room temperature for 30 min. The precipitate was filtered off and dried in vacuo. The 5-amino-1-methyl-3,6-dihydro-1H-pyrazin-2-one hydrochloride was obtained as a pale brown powder (1.7 g, 66%).

후처리

  1. temperaturerefluxed for 2 h
  2. temperatureThe reaction mixture was cooled to room temperature
  3. customevaporated under reduced pressure
  4. customThe residue was triturated with chloroform at room temperature for 30 min
  5. filtrationThe precipitate was filtered off
  6. customdried in vacuo

출처 및 근거

ORD 기록
ord-3c39366ceb154f6bb335e0b81a8b86bf
출처 데이터셋
uspto-grants-2010_10
특허 번호
US07812014B2

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