(R)-3-(5-chloroindole-2-carbonylamino)-3,4-dihydrocarbostyril → (r)-3-(5-Chloroindole-2-carbonylamino)-1-cyanomethyl-3,4-dihydrocarbostyril

반응식

ClC1C=C2C(=CC=1)NC(C(N[C@@H]1CC3C(=CC=CC=3)NC1=O)=O)=C2.[Cl:25][C:26]1[CH:27]=[C:28]2[C:32](=[CH:33][CH:34]=1)[NH:31][C:30]([C:35]([NH:37][C@H:38]1[CH2:47][C:46]3[C:41](=[CH:42][CH:43]=[CH:44][CH:45]=3)[N:40]([CH2:48][C:49]#[N:50])[C:39]1=[O:51])=[O:36])=[CH:29]2.ClC1C=C2C(=CC=1)NC(C(N[C@H]1CC3C(=CC=CC=3)NC1=O)=O)=C2>>[Cl:25][C:26]1[CH:27]=[C:28]2[C:32](=[CH:33][CH:34]=1)[NH:31][C:30]([C:35]([NH:37][C@@H:38]1[CH2:47][C:46]3[C:41](=[CH:42][CH:43]=[CH:44][CH:45]=3)[N:40]([CH2:48][C:49]#[N:50])[C:39]1=[O:51])=[O:36])=[CH:29]2

참가 물질

반응물 3

HCID 9840862(R)-3-(5-chloroindole-2-carbonylamino)-3,4-dihydrocarbostyril

HCID 44357926(S)-3-(5-chloroindole-2-carbonylamino)-3,4-dihydrocarbostyril

HCID 87730389(S)-3-(5-chloroindole-2-carbonylamino)-1-cyanomethyl-3,4-dihydrocarbostyril

생성물 1

HCID 87730651(r)-3-(5-Chloroindole-2-carbonylamino)-1-cyanomethyl-3,4-dihydrocarbostyril

실험 절차

The title compound was prepared from (R)-3-(5-chloroindole-2-carbonylamino)-3,4-dihydrocarbostyril (Example 3) by the procedures described for the preparation of (S)-3-(5-chloroindole-2-carbonylamino)-1-cyanomethyl-3,4-dihydrocarbostyril (Example 17) from (S)-3-(5-chloroindole-2-carbonylamino)-3,4-dihydrocarbostyril. HPLC/MS [M+H]+, 379.