Acetonitrile → 1-Benzyl-1H-indole-3-carboxylic acid pyrimidin-4-ylamide

HRID 1159134

반응식

HRID 1159134 반응식
[CH2:1]([N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[C:10]([C:17]([OH:19])=O)=[CH:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[N:20]1[CH:25]=[CH:24][C:23]([NH2:26])=[N:22][CH:21]=1.CC#N>O=S(Cl)Cl.CN1C(=O)CCC1>[N:20]1[CH:25]=[CH:24][C:23]([NH:26][C:17]([C:10]2[C:11]3[C:16](=[CH:15][CH:14]=[CH:13][CH:12]=3)[N:8]([CH2:1][C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)[CH:9]=2)=[O:19])=[N:22][CH:21]=1

참가 물질

6

반응물 3

HCID 6342AcetonitrileHCID 336711-benzyl-1H-indole-3-carboxylic acidHCID 689584-Aminopyrimidine

생성물 1

HCID 595139721-Benzyl-1H-indole-3-carboxylic acid pyrimidin-4-ylamide

시약·촉매·용매 2

HCID 13387N-methyl-2-pyrrolidone용매HCID 24386Thionyl Chloride용매

실험 절차

1-Benzylindole-3-carboxylic acid (25.9 mg, 96 mmol) was dissolved in SOCl2 (1 mL) and the mixture was stirred for 30 min before the volatiles were removed in vacuo. The residue was dissolved in MeCN (200 μL) and added to a solution of pyrimidin-4-yl-amine (10 mg, 105 mmol) in NMP (200 μL). The reaction mixture was stirred 16 hours at room temperature before the MeCN was removed in vacuo. The residue was purified using HPLC method D to give title compound.

후처리

  1. customwere removed in vacuo
  2. dissolutionThe residue was dissolved in MeCN (200 μL)
  3. customwas removed in vacuo
  4. customThe residue was purified

출처 및 근거

ORD 기록
ord-481fb1c78bb44715b4b824227f0f607e
출처 데이터셋
uspto-grants-2010_10
특허 번호
US07812043B2

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