Formamidine acetate → HCID 178435739, 화합물

HRID 1159184노트

반응식

HRID 1159184 반응식
[CH2:1]([C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]=1[C:11]([CH2:13][CH:14]([NH2:17])[CH2:15][NH2:16])=[CH:10][CH:9]=[CH:8]2)[CH3:2].[C:18](O)(=O)C.C(N)=N>CCO>[CH2:1]([C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]=1[C:11]([CH2:13][CH:14]1[CH2:15][NH:16][CH:18]=[N:17]1)=[CH:10][CH:9]=[CH:8]2)[CH3:2]

참가 물질

4

반응물 2

HCID 160693Formamidine acetateHCID 575431993-(8-Ethyl-naphthalen-1-yl)-propane-1,2-diamine

생성물 1

HCID 178435739HCID 178435739, 화합물수율 60.7%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution of 3-(8-ethyl-naphthalen-1-yl)-propane-1,2-diamine (60 mg) in EtOH (6 ml) was treated at r.t. under an argon atmosphere with formamidine acetate (30 mg). The reaction mixture was stirred at r.t. overnight, then concentrated. The crude product was purified by column chromatography (silica gel; eluent: CH2Cl2→CH2Cl2/MeOH 9:1) to give (RS)-4-(8-ethyl-naphthalen-1-ylmethyl)-4,5-dihydro-1H-imidazole (38 mg) as light yellow gum. MS (ISP): 239.3 ((M+H)+).

후처리

  1. concentrationconcentrated
  2. customThe crude product was purified by column chromatography (silica gel; eluent: CH2Cl2→CH2Cl2/MeOH 9:1)

출처 및 근거

ORD 기록
ord-dbb51d7f49384948ad7b6168a2413755
출처 데이터셋
uspto-grants-2010_10
특허 번호
US07812047B2

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