2-Fluoro-5-methylphenyl isocyanate → N-[4-(3-amino-1-methyl-1H-pyrazolo[3,4-c]pyridin-4-yl)phenyl]-N'-(3-chloro-4-fluorophenyl)urea

참여 물질

역할	이름	HCID	투입량
반응물	2-Fluoro-5-methylphenyl isocyanate	HCID 2733377	—
반응물	3-Chloro-4-fluorophenyl isocyanate	HCID 2734632	—
반응물	4-(4-Amino-phenyl)-1-methyl-1H-pyrazolo[3,4-c]pyridin-3-ylamine	HCID 68644474	—
생성물	N-[4-(3-amino-1-methyl-1H-pyrazolo[3,4-c]pyridin-4-yl)phenyl]-N'-(3-chloro-4-fluorophenyl)urea	HCID 11517151	—

반응 단계

The title compound was prepared using the procedure described in Example 1E using the product from Example 6A and 2-chloro-1-fluoro-4-isocyanato-benzene instead of the product from Example 1D and 1-fluoro-2-isocyanato-4-methyl-benzene. MS (ESI(+)) m/e 411 (M+H)+; 1H NMR (300 MHz, DMSO-D6) δ ppm 3.92 (s, 3H) 4.61-4.72 (m, 2H) 7.32-7.37 (m, 2H) 7.47 (d, J=8.82 Hz, 2H) 7.63 (d, J=8.82 Hz, 2H) 7.79-7.84 (m, 1H) 7.94 (s, 1H) 8.87 (s, 1H) 8.95 (s, 1H) 8.96 (s, 1H).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07812166B2
출처 데이터셋	uspto-grants-2010_10
ORD ID	ord-1b3f44accb7f4c59884ebb17428c3dac
출처 메모	uspto-grants-2010_10