3-(4-Hydroxypiperidin-1-yl)propanenitrile → 3-[2-(4-hydroxypiperidin-1-yl)ethyl]-2H-isoquinolin-1-one

반응식

C([N:3]([CH2:14][CH3:15])[C:4](=[O:13])[C:5]1[CH:10]=[CH:9][CH:8]=[C:7](C)[C:6]=1[CH3:12])C.[OH:16][CH:17]1[CH2:22][CH2:21][N:20]([CH2:23]CC#N)[CH2:19][CH2:18]1>>[OH:16][CH:17]1[CH2:22][CH2:21][N:20]([CH2:23][CH2:15][C:14]2[NH:3][C:4](=[O:13])[C:5]3[C:6]([CH:12]=2)=[CH:7][CH:8]=[CH:9][CH:10]=3)[CH2:19][CH2:18]1

참가 물질

반응물 2

HCID 127257493-(4-Hydroxypiperidin-1-yl)propanenitrile

HCID 15621069N,N-Diethyl-2,3-dimethylbenzamide

생성물 1

HCID 104233773-[2-(4-hydroxypiperidin-1-yl)ethyl]-2H-isoquinolin-1-one수율 8.2%

실험 절차

By the reaction in the same manner as in Example 1a, using N,N-diethyl-2,3-dimethylbenzamide (5.6017 g) and 3-(4-hydroxypiperidin-1-yl)propionitrile (2.26 g), 3-[2-(4-hydroxypiperidin-1-yl)ethyl]-2H-isoquinolin-1-one (327.5 mg) was obtained.

후처리

customBy the reaction in the same manner as in Example 1a

출처 및 근거

ORD 기록: ord-3294e3aa69ca4df7a87338fc3b6250d7
출처 데이터셋: uspto-grants-2010_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07812178B2

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