N,N-Diethyl-2,3-dimethylbenzamide → HCID 58863440, 화합물

HRID 1159552노트

반응식

HRID 1159552 반응식
[OH:1][C@@H:2]1[CH2:6][N:5]([CH2:7][CH2:8][C:9]#[N:10])[C@@H:4]([CH2:11][OH:12])[CH2:3]1.C(N(CC)[C:16](=[O:25])[C:17]1[CH:22]=[CH:21][CH:20]=[C:19]([CH3:23])[C:18]=1[CH3:24])C>>[OH:1][C@@H:2]1[CH2:6][N:5]([CH2:7][CH2:8][C:9]2[NH:10][C:16](=[O:25])[C:17]3[C:18]([CH:24]=2)=[C:19]([CH3:23])[CH:20]=[CH:21][CH:22]=3)[C@@H:4]([CH2:11][OH:12])[CH2:3]1

참가 물질

3

반응물 2

HCID 15621069N,N-Diethyl-2,3-dimethylbenzamideHCID 68644380HCID 68644380, 화합물

생성물 1

HCID 58863440HCID 58863440, 화합물수율 16.8%

실험 절차

In the same manner as in Example 1b (e) and using 3-[(2R,4S)-4-hydroxy-2-hydroxymethylpyrrolidin-1-yl]propionitrile (0.47 g) and N,N-diethyl-2,3-dimethylbenzamide (2.1 g), 3-{2-[(2R,4S)-4-hydroxy-2-hydroxymethylpyrrolidin-1-yl]ethyl}-5-methyl-2H-isoquinolin-1-one (0.14 g) was obtained.

출처 및 근거

ORD 기록
ord-4160c2f2a5e24aa894d20a73de81f692
출처 데이터셋
uspto-grants-2010_10
특허 번호
US07812178B2

반응 노트

불러오는 중…