2,2-Dimethyl-3,4-epoxy-6-cyanochroman → 4-(2-Amino-quinolin-4-yloxy)-3-hydroxy-2,2-dimethyl-chroman-6-carbonitrile

HRID 1159598

반응식

HRID 1159598 반응식
[CH3:1][C:2]1([CH3:15])[O:11][C:10]2[C:5](=[CH:6][C:7]([C:12]#[N:13])=[CH:8][CH:9]=2)[CH:4]2[O:14][CH:3]12.[NH2:16][C:17]1[CH:26]=[C:25]([OH:27])[C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[N:18]=1>>[NH2:16][C:17]1[CH:26]=[C:25]([O:27][CH:4]2[C:5]3[C:10](=[CH:9][CH:8]=[C:7]([C:12]#[N:13])[CH:6]=3)[O:11][C:2]([CH3:1])([CH3:15])[CH:3]2[OH:14])[C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[N:18]=1

참가 물질

3

반응물 2

HCID 108673602,2-Dimethyl-3,4-epoxy-6-cyanochromanHCID 178507928HCID 178507928, 화합물

생성물 1

HCID 160406594-(2-Amino-quinolin-4-yloxy)-3-hydroxy-2,2-dimethyl-chroman-6-carbonitrile

실험 절차

Following the procedure in Example 1, using (±)-2,2-dimethyl-1a,7b-dihydro-2H-1,3-dioxa-cyclopropa[a]naphthalene-6-carbonitrile and 2-amino-quinolin-4-ol as starting materials, the title compound was prepared as a white solid.

출처 및 근거

ORD 기록
ord-e8e5da45147e4826862ad59ba1966349
출처 데이터셋
uspto-grants-2010_10
특허 번호
US07812183B2

연결된 노트

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