Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzylsulfonic acid → 5-(Phenylmethoxy)-1-phenylsulfonylindole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzylsulfonic acid | HCID 7532 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | Bis(tetrabutylammonium) sulphate | HCID 11433187 | — |
| 반응물 | 5-Benzyloxoindole | HCID 68714216 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 5-(Phenylmethoxy)-1-phenylsulfonylindole | HCID 11824624 | 83% |
반응 단계
DCM (200 mL) was added to 5-benzyloxoindole (15 g, 67 mmol), benzylsulfonic acid (17.8 g, 101 mmol) and tetrabutyl ammoniumsulfat (6.84 g, 20 mmol) followed by 5 M NaOH (40 mL). The reaction mixture was stirred at rt for 3 h. The aqueous layer was washed with DCM (2×30 mL) and the organic layers were combined and washed with brine (30 mL). Drying (MgSO4) and concentration in vacco was followed by crystallization from MeOH to give the product in 83% yield (20.3 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07812017B2 |
| 출처 데이터셋 | uspto-grants-2010_10 |
| ORD ID | ord-d000031967a94d8a974ac43d6a24285f |
| 출처 메모 | uspto-grants-2010_10 |