Tris(hydroxymethyl)aminomethane → N-(3-{3-[2-(1,2,3,4-tetrahydro-7-isoquinolinylamino)-4-pyrimidinyl]-pyrazolo[1,5-a]pyridin-2-yl}phenyl)benzamide

참여 물질

반응 단계

To a solution of 100 mg (0.25 mmol) of 4-[2-(3-aminophenyl)pyrazolo[1,5-a]pyridin-3-yl]-N-(3-fluorophenyl)-2-pyrimidinamine in THF at rt was added 63 mg (0.353 mmol) of 3-pyridinecarbonyl chloride. The reaction mixture was allowed to stir for 30 min. At this time, 3.0 eq of PS-Trisamine resin was added and the resulting slurry was allowed to stir overnight. Excess triethylamine was added and the resin was removed by filtration. The reaction mixture was concentrated to dryness and the product was triturated from DCM to give 20 mg of the title compound as a yellow solid: 1H-NMR (d6-DMSO, 400 MHz) δ 6.59 (d, 1H, J=5.5 Hz), 6.73 (td, 1H, J=7.9 and 2.5 Hz), 7.14 (td, 1H, J=7.0 and 1.5 Hz), 7.26 (dd, 1H, J=15.2 and 6.9 Hz), 7.35 (d, 1H, J=7.6 Hz), 7.45-7.58 (m, 4H), 7.80 (d, 1H, J=12.0 Hz), 7.95 (d, 1H, J=8.2 Hz), 8.10 (s, 1H), 8.29 (d, 1H, J=8.6 Hz), 8.32 (d, 1H, J=5.4 Hz), 8.50 (d, 1H, J=8.6 Hz), 8.76 (dd, 1H, J=4.7 and 1.5 Hz), 8.86 (d, 1H, J=7.1 Hz), 9.10 (s, 1H), 9.81 (s, 1H), and 10.57 (s, 1H); HRMS calcd for C29H20FN7O: 501.1713, found: 502.1801 (M+H+).

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