5-(Methylthio)-2-nitroaniline → HCID 20393009, 화합물

HRID 1160168

반응식

HRID 1160168 반응식
[CH3:1][S:2][C:3]1[CH:4]=[CH:5][C:6]([N+:10]([O-])=O)=[C:7]([CH:9]=1)[NH2:8]>C(O)(=O)C.[Zn]>[CH3:1][S:2][C:3]1[CH:4]=[CH:5][C:6]([NH2:10])=[C:7]([NH2:8])[CH:9]=1

참가 물질

4

반응물 1

HCID 105354825-(Methylthio)-2-nitroaniline

생성물 1

HCID 20393009HCID 20393009, 화합물수율 100.9%

시약·촉매·용매 2

HCID 23994Zinc촉매HCID 176Acetic Acid용매

반응 조건

온도
85 °C

실험 절차

A solution of 5-methylthio-2-nitroaniline (50 mg; 0.27 mmol) in acetic acid (2 ml) was heated to 85° C. Zinc powder (71 mg; 1.09 mmol) was then added portionwise over 15 minutes and the resulting solution was maintained at 85° C. for 2 hours. The hot reaction mixture was then filtered through celite and the filter cake washed with hot acetic acid (10 ml). The filtrate was evaporated to dryness to give crude 4-methylthio-1,2-phenylenediamine (42 mg, 100%). This was used directly in the next step without purification.

후처리

  1. filtrationThe hot reaction mixture was then filtered through celite
  2. washthe filter cake washed with hot acetic acid (10 ml)
  3. customThe filtrate was evaporated to dryness

출처 및 근거

ORD 기록
ord-680012fb0c2e4520b00d0e1c4239d0ee
출처 데이터셋
uspto-grants-2010_10
특허 번호
US07816369B2

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