Tetrahydrofuran → (R)-3-(3-Fluorophenyl)-5-(hydroxymethyl)oxazolidin-2-one

온도

-78 °C

132 g of N-carbobenzyloxy-3-fluoroaniline 132 g prepared in the Preparation example 1 was dissolved in 1.3 L of tetrahydrofuran and the solution was cooled to −78° C. 370 ml of n-buthyllitium (n-BuLi, 1.6M/n-hexane) was slowly added to the solution in a nitrogen atmosphere, followed by stirring for 10 min. And 84 ml of (R)-(−)-glycidylbuthylate was slowly added to the reaction mixture, stirred at the same temperature for 2 hours and allowed to react for 24 hours at room temperature. After completion of the reaction, the solution was added with ammonium chloride (NH4Cl) solution and extracted with 0.5 L of ethyl acetate at room temperature. The organic layer, thus separated, was washed with brine, dried over anhydrous magnesium sulfate and concentrated in vacuo. The residue was dissolved in 100 ml of ethyl acetate and washed with n-hexane to give white crystals, which were purified to the title compound. 80 g. Yield 70%.

1. additionAnd 84 ml of (R)-(−)-glycidylbuthylate was slowly added to the reaction mixture
2. stirringstirred at the same temperature for 2 hours
3. customto react for 24 hours at room temperature
4. customAfter completion of the reaction
5. extractionextracted with 0.5 L of ethyl acetate at room temperature
6. customThe organic layer, thus separated
7. washwas washed with brine
8. dry with materialdried over anhydrous magnesium sulfate
9. concentrationconcentrated in vacuo
10. dissolutionThe residue was dissolved in 100 ml of ethyl acetate
11. washwashed with n-hexane
12. customto give white crystals, which
13. customwere purified to the title compound

ORD 기록

ord-546f43c76191422e88531931cfd1686a

출처 데이터셋

uspto-grants-2010_10

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US07816379B2