Thionyl Chloride → 2-(Chloromethyl)-5-(trifluoromethyl)pyridine

HRID 1160221노트

반응식

HRID 1160221 반응식
[ClH:1].[F:2][C:3]([F:13])([F:12])[C:4]1[CH:5]=[CH:6][C:7]([CH2:10]O)=[N:8][CH:9]=1.O=S(Cl)[Cl:16]>>[Cl:16][CH2:10][C:7]1[CH:6]=[CH:5][C:4]([C:3]([F:13])([F:12])[F:2])=[CH:9][N:8]=1.[ClH:1].[Cl:16][CH2:10][C:7]1[CH:6]=[CH:5][C:4]([C:3]([F:13])([F:12])[F:2])=[CH:9][N:8]=1

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 68694003(5-(trifluoromethyl)pyridin-2-yl)methanol HCl salt

생성물 2

HCID 183617202-(Chloromethyl)-5-(trifluoromethyl)pyridineHCID 686914462-(Chloromethyl)-5-(trifluoromethyl)pyridine hydrochloride

실험 절차

The mixture of (5-(trifluoromethyl)pyridin-2-yl)methanol HCl salt (293 mg, 1.4 mmol) and SOCl2 (1.5 ml) was stirred for 10 min. After this time, the solution was concentrated under reduced pressure to give the title compound, 2-(chloromethyl)-5-(trifluoromethyl)pyridine HCl salt.

후처리

  1. concentrationAfter this time, the solution was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-35205fb3e7a441dd9cf647040934d051
출처 데이터셋
uspto-grants-2010_10
특허 번호
US07816357B2

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