Indole-3-Carboxylic Acid → N-(2-(2-tert-butylphenoxy)pyridin-3-yl)-1H-indole-3-carboxamide

반응식

[C:1]([C:5]1[CH:20]=[CH:19][CH:18]=[CH:17][C:6]=1[O:7][C:8]1[C:13]([N:14]=[C:15]=[O:16])=[CH:12][CH:11]=[CH:10][N:9]=1)([CH3:4])([CH3:3])[CH3:2].[NH:21]1[C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)[C:23](C(O)=O)=[CH:22]1>>[C:1]([C:5]1[CH:20]=[CH:19][CH:18]=[CH:17][C:6]=1[O:7][C:8]1[C:13]([NH:14][C:15]([C:23]2[C:24]3[C:29](=[CH:28][CH:27]=[CH:26][CH:25]=3)[NH:21][CH:22]=2)=[O:16])=[CH:12][CH:11]=[CH:10][N:9]=1)([CH3:4])([CH3:2])[CH3:3]

참가 물질

반응물 2

HCID 69867Indole-3-Carboxylic Acid

HCID 574233152-(2-tert-Butylphenoxy)-3-isocyanatopyridine

생성물 1

HCID 67026890N-(2-(2-tert-butylphenoxy)pyridin-3-yl)-1H-indole-3-carboxamide

실험 절차

Example 72 was prepared from 2-(2-tert-butylphenoxy)pyridin-3-amine (1a) and 1H-indole-3-carboxylic acid using the procedure described for Example 70. LC-MS m/z 386.2 [M+H]+.

출처 및 근거

ORD 기록: ord-d42180b1b4bc497fba5bc0761af7ca49
출처 데이터셋: uspto-grants-2010_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07816382B2

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