Trifluoroacetic acid → (3S)-3-[(3-chloro-4-cyanophenyl)amino]-4-[(1-methylethyl)amino]butanoic acid hydrochloride

HRID 1160404노트

반응식

HRID 1160404 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([NH:10][C@H:11]([CH2:20][NH:21][CH:22]([CH3:24])[CH3:23])[CH2:12][C:13]([O:15]C(C)(C)C)=[O:14])[CH:5]=[CH:6][C:7]=1[C:8]#[N:9].C(O)(C(F)(F)F)=O>C(Cl)Cl>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]([NH:10][C@H:11]([CH2:20][NH:21][CH:22]([CH3:24])[CH3:23])[CH2:12][C:13]([OH:15])=[O:14])[CH:5]=[CH:6][C:7]=1[C:8]#[N:9]

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 595162251,1-Dimethylethyl (3S)-3-[(3-chloro-4-cyanophenyl)amino]-4-[(1-methylethyl)amino]butanoate

생성물 1

HCID 68484641(3S)-3-[(3-chloro-4-cyanophenyl)amino]-4-[(1-methylethyl)amino]butanoic acid hydrochloride

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A solution of 1,1-dimethylethyl (3S)-3-[(3-chloro-4-cyanophenyl)amino]-4-[(1-methylethyl)amino]butanoate (0.33 g, 0.94 mmol) in CH2Cl2 (2 mL) was treated with TFA (1 mL) for 1.5 h and the reaction was evaporated thoroughly. The residue was treated with 4N HCl in dioxane (4 mL) and then concentrated (this step was done twice) and the crude product was used directly in the next step.

후처리

  1. customthe reaction was evaporated thoroughly
  2. additionThe residue was treated with 4N HCl in dioxane (4 mL)
  3. concentrationconcentrated (this step

출처 및 근거

ORD 기록
ord-3a71f1f5eb4d434a888f348f917d3235
출처 데이터셋
uspto-grants-2010_10
특허 번호
US07816395B2

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