2,7-Dibromo-9-fluorenone → 9-(2-Biphenylyl)-2,7-dibromo-9-fluorenol

HRID 1160981

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HRID 1160981 반응식
[Br:1][C:2]1[CH:14]=[CH:13][C:12]2[C:11]3[C:6](=[CH:7][C:8]([Br:15])=[CH:9][CH:10]=3)[C:5](=[O:16])[C:4]=2[CH:3]=1>C(OCC)C>[C:11]1([C:12]2[CH:4]=[CH:3][CH:2]=[CH:14][CH:13]=2)[CH:6]=[CH:7][CH:8]=[CH:9][C:10]=1[C:5]1([OH:16])[C:4]2[CH:3]=[C:2]([Br:1])[CH:14]=[CH:13][C:12]=2[C:11]2[C:6]1=[CH:7][C:8]([Br:15])=[CH:9][CH:10]=2

참가 물질

3

반응물 1

HCID 2599222,7-Dibromo-9-fluorenone

생성물 1

HCID 220160479-(2-Biphenylyl)-2,7-dibromo-9-fluorenol수율 198.7%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

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온도
50 °C

실험 절차

15.2 g (45 mmol) of 2,7-dibromo-9-fluorenone was put in a 100 mL three-necked flask, and nitrogen substitution was conducted. 40 mL of diethyl ether was added. The Grignard reagent above was transferred into a dropping funnel by a cannula so as not to expose it to the atmosphere, and was added dropwise into the mixture. The mixture was refluxed at 50° C. After the reaction, the solution was washed with water. Then the aqueous layer was extracted with ethyl acetate and combined with the organic layer. The layers were washed with a saturated saline solution, then dried with magnesium sulfate. Filtration and concentration were carried out, and 22 g of 9-(biphenyl-2-yl)-2,7-dibromo-9-fluorenol was obtained as a white solid, in a yield of 90%.

후처리

  1. additionwas added dropwise into the mixture
  2. customAfter the reaction
  3. washthe solution was washed with water
  4. extractionThen the aqueous layer was extracted with ethyl acetate
  5. washThe layers were washed with a saturated saline solution
  6. dry with materialdried with magnesium sulfate
  7. filtrationFiltration and concentration

출처 및 근거

ORD 기록
ord-7d33e105262d4616b2243ceaa7b99bc3
출처 데이터셋
uspto-grants-2010_10
특허 번호
US07816668B2

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