Methanol → (S)-2-(5-Amino-1-oxoisoquinolin-2(1H)-yl)propanamide

HRID 1161200노트

반응식

HRID 1161200 반응식
[N+:1]([C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][N:8]([C@@H:15]([CH3:19])[C:16]([NH2:18])=[O:17])[C:9]2=[O:14])([O-])=O.CO>[Pd].ClCCl>[NH2:1][C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][N:8]([C@@H:15]([CH3:19])[C:16]([NH2:18])=[O:17])[C:9]2=[O:14]

참가 물질

5

반응물 2

HCID 887MethanolHCID 59515862(S)-2-(5-Nitro-1-oxoisoquinolin-2(1H)-yl)propanamide

생성물 1

HCID 59515789(S)-2-(5-Amino-1-oxoisoquinolin-2(1H)-yl)propanamide

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 6344Dichloromethane용매

실험 절차

A round bottom flask was charged with (S)-2-(5-nitro-1-oxoisoquinolin-2(1H)-yl)propanamide (1.3 g, 0.0050 mol),methanol (40 mL, 1 mol), dichloromethane (5 mL) and palladium on charcoal (0.2 g, 0.001 mol) were added and the mixture was stirred under hydrogen (1 atm) for 2 h. The reaction mixture was filtered over celite and the solvent removed under reduced pressure to yield the pure product as an off white solid. MS m/z=232.5 (M+H).

후처리

  1. additionwere added
  2. filtrationThe reaction mixture was filtered over celite
  3. customthe solvent removed under reduced pressure
  4. customto yield the pure product as an off white solid

출처 및 근거

ORD 기록
ord-a453a90276da4f6cb8b83da4d55dfabe
출처 데이터셋
uspto-grants-2010_10
특허 번호
US07816371B2

반응 노트

불러오는 중…