Methanol → (R)-2-(5-Amino-1-oxoisoquinolin-2(1H)-yl)propanamide

HRID 1161203노트

반응식

HRID 1161203 반응식
[N+:1]([C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][N:8]([C@H:15]([CH3:19])[C:16]([NH2:18])=[O:17])[C:9]2=[O:14])([O-])=O.CO>[Pd].C(OC(=O)C)C>[NH2:1][C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][N:8]([C@H:15]([CH3:19])[C:16]([NH2:18])=[O:17])[C:9]2=[O:14]

참가 물질

5

반응물 2

HCID 887MethanolHCID 59515648(R)-2-(5-Nitro-1-oxoisoquinolin-2(1H)-yl)propanamide

생성물 1

HCID 59515719(R)-2-(5-Amino-1-oxoisoquinolin-2(1H)-yl)propanamide

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8857Ethyl Acetate용매

실험 절차

A round bottom flask was charged with (R)-2-(5-nitro-1-oxoisoquinolin-2(1H)-yl)propanamide (5.0 g, 0.018 mol), palladium on charcoal (10%) (0.3 g, 0.003 mol) and methanol (200 mL, 5 mol) and ethylacetate (80 mL). The reaction mixture was stirred under hydrogen (1 atm) at room temperature for 40 minutes. The mixture was filtered over celite, the solvent was removed to yield the product as a light yellow solid. MS m/z=232.3 (M+H).

후처리

  1. filtrationThe mixture was filtered over celite
  2. customthe solvent was removed

출처 및 근거

ORD 기록
ord-64195eda6fb0403d95b6686d34fb1398
출처 데이터셋
uspto-grants-2010_10
특허 번호
US07816371B2

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