Ethanol → (R)-2-(5-Amino-6-cyclopropyl-1-oxoisoquinolin-2(1H)-yl)propyl acetate

HRID 1161281노트

반응식

HRID 1161281 반응식
[C:1]([O:4][CH2:5][C@H:6]([N:8]1[CH:17]=[CH:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([CH:21]3[CH2:23][CH2:22]3)[C:14]=2[N+:18]([O-])=O)[C:9]1=[O:24])[CH3:7])(=[O:3])[CH3:2].C(O)C>[Pd]>[C:1]([O:4][CH2:5][C@H:6]([N:8]1[CH:17]=[CH:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([CH:21]3[CH2:22][CH2:23]3)[C:14]=2[NH2:18])[C:9]1=[O:24])[CH3:7])(=[O:3])[CH3:2]

참가 물질

4

반응물 2

HCID 702EthanolHCID 59515735(R)-2-(6-Cyclopropyl-5-nitro-1-oxoisoquinolin-2(1H)-yl)propyl acetate

생성물 1

HCID 59515874(R)-2-(5-Amino-6-cyclopropyl-1-oxoisoquinolin-2(1H)-yl)propyl acetate

시약·촉매·용매 1

HCID 23938Palladium촉매

실험 절차

A round bottom flask was charged with (R)-2-(6-cyclopropyl-5-nitro-1-oxoisoquinolin-2(1H)-yl)propyl acetate (28 mg, 0.000085 mol), ethanol (10 mL, 0.2 mol) and palladium, 10% weight on charcoal (1.0 mg, 0.0000085 mol) was added and the flask was evacuated of any air and flushed with hydrogen two times and the reaction was stirred at room temperature under hydrogen (1 atm) for 2 hours. The reaction was filtered over celite and the solvent removed to obtain the product. MS m/z=301.2 (M+H).

후처리

  1. additionwas added
  2. customthe flask was evacuated of any air
  3. customflushed with hydrogen two times
  4. filtrationThe reaction was filtered over celite
  5. customthe solvent removed
  6. customto obtain the product

출처 및 근거

ORD 기록
ord-9f87864a7d484e4c99af61e6ba7c4e25
출처 데이터셋
uspto-grants-2010_10
특허 번호
US07816371B2

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