Dichloromethane → 2-Chloro-6-(1H-pyrrol-1-yl)benzonitrile

HRID 1161637노트

반응식

HRID 1161637 반응식
[NH2:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([Cl:10])[C:3]=1[C:4]#[N:5].CO[CH:13]1[CH2:17][CH2:16][CH:15](OC)O1.Cl.ClC1C=CN=CC=1.ClCCl>O1CCOCC1>[Cl:10][C:6]1[C:3]([C:4]#[N:5])=[C:2]([N:1]2[CH:13]=[CH:17][CH:16]=[CH:15]2)[CH:9]=[CH:8][CH:7]=1

참가 물질

6

반응물 4

HCID 6344DichloromethaneHCID 790982,5-DimethoxytetrahydrofuranHCID 810562-Amino-6-chlorobenzonitrileHCID 818524-Chloropyridine hydrochloride

생성물 1

HCID 6087322-Chloro-6-(1H-pyrrol-1-yl)benzonitrile수율 87.8%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

A solution of 2-amino-6-chloro-benzonitrile (30 g), 2,5-dimethoxytetrahydrofuran (30 g) and 4-chloropyridine hydrochloride (17 g) in dioxane was heated to 70° C. for 2.5 h. The solvent was evaproated in vacuo. Dichloromethane was then added to the residue and the spent 4-chloropyridine hydrochloride filtered off. The dichloromethane was evaporated in vacuo to give 1-(3′chloro-2′-cyanophenyl)pyrrole (35 g)

후처리

  1. filtrationthe spent 4-chloropyridine hydrochloride filtered off
  2. customThe dichloromethane was evaporated in vacuo

출처 및 근거

ORD 기록
ord-34a8eaef4f56471e8a024e60b5043647
출처 데이터셋
uspto-grants-2010_10
특허 번호
US07820650B2

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