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Water → Methyl 1-allyl-7-fluoro-6-(2-fluoro-4-iodophenylamino)-1H-benzo[d]imidazole-5-carboxylate

HRID 1161786
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인쇄 미리보기

반응식

HRID 1161786 반응식
[CH2:1]([NH:4][C:5]1[C:14]([NH2:15])=[CH:13][C:8]([C:9]([O:11][CH3:12])=[O:10])=[C:7]([NH:16][C:17]2[CH:22]=[CH:21][C:20]([I:23])=[CH:19][C:18]=2[F:24])[C:6]=1[F:25])[CH:2]=[CH2:3].[C:26](O)(=O)C.C(N)=O.C(=O)(O)[O-].[Na+].O>CO>[CH2:1]([N:4]1[C:5]2[C:6]([F:25])=[C:7]([NH:16][C:17]3[CH:22]=[CH:21][C:20]([I:23])=[CH:19][C:18]=3[F:24])[C:8]([C:9]([O:11][CH3:12])=[O:10])=[CH:13][C:14]=2[N:15]=[CH:26]1)[CH:2]=[CH2:3]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 962WaterHCID 516892Sodium BicarbonateHCID 19966309Formamide acetateHCID 58781154Methyl 4-(allylamino)-5-amino-3-fluoro-2-(2-fluoro-4-iodophenylamino)benzoate

생성물 1

HCID 58781150Methyl 1-allyl-7-fluoro-6-(2-fluoro-4-iodophenylamino)-1H-benzo[d]imidazole-5-carboxylate

시약·촉매·용매 1

HCID 887
Methanol
용매

실험 절차

A stirred suspension of methyl 4-(allylamino)-5-amino-3-fluoro-2-(2-fluoro-4-iodophenylamino)benzoate (3.4 g, 7.4 mmoles)) and formamide acetate (3.8 g, 36.4 mmoles) in methanol (30 ml) is heated under reflux for 3 hours. The reaction mixture is cooled to room temperature and a saturated aqueous solution of sodium bicarbonate (30 ml) and water (30 ml) are added. The resulting precipitate is filtered and dried under vacuum to obtain the title compound.

후처리

  1. temperatureis heated
  2. temperatureunder reflux for 3 hours
  3. filtrationThe resulting precipitate is filtered
  4. customdried under vacuum

출처 및 근거

ORD 기록
ord-eb54832d575d4056b9c77ded62d0c44a
출처 데이터셋
uspto-grants-2010_10
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07820664B2

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