HCID 59519026, 화합물 → HCID 59519020, 화합물

HRID 1161866노트

반응식

HRID 1161866 반응식
C(OC([N:8]1[CH2:14][CH2:13][CH2:12][N:11]([C:15]2[CH:16]=[C:17]3[C:22](=[CH:23][CH:24]=2)[N:21]=[C:20]([C:25]2[CH:30]=[CH:29][CH:28]=[C:27]([O:31][CH3:32])[CH:26]=2)[N:19]([CH2:33][C:34](=[O:39])[NH:35][CH:36]([CH3:38])[CH3:37])[C:18]3=[O:40])[CH2:10][CH2:9]1)=O)(C)(C)C>Cl.CO>[CH:36]([NH:35][C:34](=[O:39])[CH2:33][N:19]1[C:18](=[O:40])[C:17]2[C:22](=[CH:23][CH:24]=[C:15]([N:11]3[CH2:12][CH2:13][CH2:14][NH:8][CH2:9][CH2:10]3)[CH:16]=2)[N:21]=[C:20]1[C:25]1[CH:30]=[CH:29][CH:28]=[C:27]([O:31][CH3:32])[CH:26]=1)([CH3:38])[CH3:37]

참가 물질

3

반응물 1

HCID 59519026HCID 59519026, 화합물

생성물 1

HCID 59519020HCID 59519020, 화합물수율 100%

시약·촉매·용매 1

HCID 21893726Hydrochloride methanol용매

실험 절차

4-[3-(Isopropylcarbamoylmethyl)-2-(3-methoxyphenyl)-4-oxo-3,4-dihydroquinazolin-6-yl]perhydro-1,4-diazepine-1-carboxylic acid tert-butyl ester (INTERMEDIATE VII.1) (50 mg, 0.091 mmol) was treated with 4 N HCl/MeOH (10 mL) and the resulting solution was stirred at room temperature for 2 h. The reaction mixture was concentrated in vacuo to afford N-isopropyl-2-[2-(3-methoxyphenyl)-4-oxo-6-perhydro-1,4-diazepin-1-yl-4H-quinazolin-3-yl]acetamide (EXAMPLE 2a) (40 mg, 0.091 mmol, 100%) as the hydrochloride salt. Data for N-isopropyl-2-[2-(3-methoxyphenyl)-4-oxo-6-perhydro-1,4-diazepin-1-yl-4H-quinazolin-3-yl]acetamide (EXAMPLE 2a) (EXAMPLE 2a) hydrochloride salt: MS (ESI) m/z: 450 ([M+H]+)

후처리

  1. concentrationThe reaction mixture was concentrated in vacuo

출처 및 근거

ORD 기록
ord-1869ef190ef0460e8712a28d9731b406
출처 데이터셋
uspto-grants-2010_10
특허 번호
US07820649B2

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