참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 8-benzyloxy-5-bromo-3-methyl-1H-quinolin-2-one | HCID 22499211 | — |
| 반응물 | Tri(butyl)vinyltin | HCID 53438229 | — |
| 촉매 | Tetrakis(triphenylphosphine)palladium | HCID 11979704 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 8-Benzyloxy-3-methyl-5-vinyl-1H-quinolin-2-one | HCID 22499178 | — |
반응 단계
Palladium terakis(triphenylphosphine) (30 mg) is added to a solution of 8-benzyloxy-5-bromo-3-methyl-1H-quinolin-2-one (239 mg) and tributylvinyltin (203 μL) in toluene (7 mL) at room temperature. The reaction mixture is heated for 2 hours at 100° C., cooled to room temperature, evaporated and the product purified by flash column chromatography on silica gel, eluting with 2% ethyl acetate in dichloromethane.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07820694B2 |
|---|
| 출처 데이터셋 | uspto-grants-2010_10 |
|---|
| ORD ID | ord-60f146b7f5ed4fb2801acb61ad4fe57f |
|---|
| 출처 메모 | uspto-grants-2010_10 |
|---|
