4-Fluorobenzyl chloride → (r)-1-(4-Fluorobenzyl)-3-methylpiperazine
반응식
[CH3:1][C@@H:2]1[CH2:7][NH:6][CH2:5][CH2:4][NH:3]1.[F:8][C:9]1[CH:16]=[CH:15][C:12]([CH2:13]Cl)=[CH:11][CH:10]=1.C(=O)([O-])O.[Na+]>C(O)C>[F:8][C:9]1[CH:16]=[CH:15][C:12]([CH2:13][N:6]2[CH2:5][CH2:4][NH:3][C@H:2]([CH3:1])[CH2:7]2)=[CH:11][CH:10]=1참가 물질
5
실험 절차
To a solution of (2R)-2-methyl-piperizine (4.5 g, 45 mmol) in ethanol (80 mL) was added 4-fluorobenzyl chloride (5.38 mL, 45.0 mmol) and sodium hydrogen carbonate (11.3 g, 135 mmol). The reaction was refluxed overnight, cooled and concentrated. The remaining residue was diluted with dichloromethane and washed with water. The organic layer was separated and concentrated to give a clear oil. Chromatography on silica gel gave the title compound (5.0 g).
후처리
- temperatureThe reaction was refluxed overnight
- temperaturecooled
- concentrationconcentrated
- additionThe remaining residue was diluted with dichloromethane
- washwashed with water
- customThe organic layer was separated
- concentrationconcentrated
- customto give a clear oil
출처 및 근거
- ORD 기록
- ord-47c853a443844d0ebba44d6152144a8d
- 출처 데이터셋
- uspto-grants-2006_08
- 특허 번호
- US07098212B2
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